The whole thing is a solid read, but two things worth quoting:

You may find sites that don’t load correctly with a content blocker in action. If so, you can reload any site without it. In Safari, all you need to do is tap and hold the reload button in the toolbar. When you do so, a menu displays asking if you want to request the desktop site, instead of the mobile site, or if you want to reload that site worth content blockers.

Good to know. And:

It’s a shame we had to get to this point. I make my living from writing, much of which is published on ad-supported websites. And I have ads on this site. So I would rather that the sleazy ad networks hadn’t killed the web, but they have.

Not sure they’ve killed the web, but they’ve certainly created the market for content blockers. And, I suspect, that will definitely change the web, at least the web’s advertising model.