Should you leave your Mac running all the time?

The Eclectic Light Company:

When did your Mac last start up? Mine’s only been running continuously now for nearly ten days, but unless something forces me to, I don’t intend restarting it for another couple of weeks, and only shut it down completely a couple of times a year. Which is better, then: a daily boot, or leaving your Mac on as long as possible?

Traditional arguments about this have been based on the last generation of computers, with internal hard drives. I’ve been leaving my desktop Mac running constantly for many years now, and started doing so largely to reduce the risk of hard drive failure. This iMac Pro no longer has internal storage which spins platters, so it’s time to reassess what I do.

This is a question as old as computers. For what it’s worth, my computer only gets shut down when it’s required by a software update.